Witchblade is an American comic book series published by Top Cow Productions, an imprint of Image Comics, from 1995 until present. The series was created by Top Cow editors Marc Silvestri and David Wohl, writers Brian Haberlin and Christina Z, and artist Michael Turner.

The series follows the lives of two disparate women in New York City, Sara Pezzini and Danielle Baptiste. Sara is a tough-as-nails NYPD homicide detective who comes into possession of the Witchblade, a supernatural, sentient artifact with immense destructive and protective powers. The weapon has bonded with various women throughout history, Danielle being the most recent. Others who have come into contact with the Witchblade include Cleopatra and Joan of Arc. Sara struggles to hone the awesome powers of the Witchblade and fend off those with a nefarious interest in it, especially entrepreneur Kenneth Irons. She also struggles to maintain a personal life.

There have been many spin-off titles which place the Witchblade in other times and settings. The character of Sara Pezzini was also featured in crossovers with characters from other franchises, including Lara Croft, JLA, and the cast of Battle of the Planets.